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Phentermine’s sympathomimetic activity increases bladder sphincter tone, which in men with any degree of prostate enlargement can cause urinary hesitancy, weak stream, or the sensation of incomplete emptying — typically in the first week of treatment
Tuberculin Test
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In humans, intravenous infusion of PP (10 pmol/kg/min) (supra-physiological levels of PP) in ten healthy volunteers (men and women of normal body weight) caused a sustained decrease in both appetite and cumulative 24-hour energy intake by 25.3 +/- 5.8% (193)